Abstract
Purpose
This meta-analysis was conducted to determine the prevalence and risk factors of fatigue in type 1 and type 2 diabetes mellitus (DM).
Methods
Observational studies reporting the prevalence and risk factors of fatigue in type 1 or 2 DM were systematically searched for in PubMed, Embase, CINAHL Plus, Cochrane Trial, and ProQuest Dissertation and Theses databases. Data were extracted by two independent reviewers. A random-effect model was used for data analysis.
Findings
We included 19 studies involving 7131 patients with type 1 DM and 32 studies involving 34,994 patients with type 2 DM in the study. The pooled prevalence of fatigue in type 1 and type 2 DM was 44% and 50%, respectively. The Asia–Pacific region (e.g., Japan and Australia), South America, and Africa lacked reports regarding fatigue prevalence in type 1 DM, and North Asia and Southeast Asia lacked reports of fatigue prevalence in type 2 DM. Depression and physical activity were the only two variables significantly correlated with fatigue in both type 1 and type 2 DM (all p < 0.05).
Conclusions
Approximately half of the patients with type 1 or type 2 DM experienced fatigue, with the prevalence of 44% and 50%, respectively. Our findings regarding its risk factors can provide an evidence-based approach for managing fatigue in DM patients.
Clinical relevance
This meta-analysis emphasizes the importance of fatigue management in patients with type 1 and type 2 DM. Most significantly, our results on risk factors related to fatigue in diabetes can contribute to the development of evidence-based strategies for managing fatigue in individuals with DM.
摘要翻譯（僅供參考）
目的
該薈萃分析旨在確定 1 型和 2 型糖尿病 (DM) 中疲勞的患病率和危險因素。
方法
在 PubMed、Embase、CINAHL Plus、Cochrane 試驗和 ProQuest 論文和論文數據庫中系統地搜索了報告 1 型或 2 型 DM 疲勞患病率和危險因素的觀察性研究。數據由兩名獨立審查員提取。隨機效應模型用於數據分析。
發現
我們納入了 19 項研究，涉及 7131 名 1 型 DM 患者，32 項研究涉及 34,994 名 2 型 DM 患者。1 型和 2 型 DM 的疲勞總患病率分別為 44% 和 50%。亞太地區（如日本和澳大利亞）、南美和非洲缺乏 1 型糖尿病疲勞患病率的報告，北亞和東南亞缺乏 2 型糖尿病疲勞患病率的報告。抑鬱和體力活動是唯一與 1 型和 2 型糖尿病患者的疲勞顯著相關的兩個變量（所有p < 0.05）。
結論
大約一半的 1 型或 2 型 DM 患者出現疲勞，患病率分別為 44% 和 50%。我們關於其風險因素的發現可以為管理 DM 患者的疲勞提供一種循證方法。
臨牀相關性
該薈萃分析強調了疲勞管理對 1 型和 2 型 DM 患者的重要性。最重要的是，我們關於糖尿病疲勞相關風險因素的結果有助於制定循證策略來管理糖尿病患者的疲勞。